Denovo Plus B12 15 mg L-Methylfolate Calcium

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DENOVO PLUS B12 is a dietary supplement designed to support the metabolic management of low folate & B12 levels associated with symptoms of  depression. Its active form of folate is priced lower than similar brands and helps produce serotonin, dopamine, and norepinephrine, essential neurotransmitters for alleviating sadness, anxiety, and gloom. Vitamin B12 at a minimum of 500mcg daily helps create energy, stimulate serotonin, and reduce stress. Patients with symptoms of depression often exhibit low levels of folate & vitamin B12. The human body needs sufficient folate intake to produce the essential neurotransmitters serotonin, dopamine, & norepinephrine when taking a minimum of 500 mcg (1/2 mg) daily.

Made in the USA

Supplement Facts

Active Ingredients: 15 mg L-methylfolate (L-5-MTHF from L-5-methyltetrahydrofolate calcium salt) & 2 mg (2,000 mcg) of vitamin B12 (as methylcobalamin).

Inactive Ingredients: microcrystalline cellulose, gelatin, vegetable magnesium stearate, silica, titanium dioxide, FD&C yellow #5k, FD&C yellow #6

Uses: Denovo is indicated for the distinct metabolic requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and or red blood cells and have a major depressive disorder (MDD) with particular emphasis as adjunctive support for individuals who are on an antidepressant medication.

L-methylfolate supplements are also used in people with major depressive disorder who have folate deficiency or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency. (Source UofMH)

Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations.) 5-MTHF may be less likely than folic acid to mask B12 deficiency. Folate therapy alone is inadequate for the treatment of B12 deficiency.

Caution is recommended in patients with a history of bipolar illness. Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder. 


Take one capsule daily or as recommended by your healthcare professional.

Each bottle contains 30 tablets.

What People Say

"After giving birth, I struggled with postpartum depression. I had been on prescription antidepressants and did not want to go on one again due to the associated side effects. Denovo was recommended to me as an alternative. It is truly a fantastic product! It worked just as well, if not better, than the antidepressants I have been on in the past. Denovo helped me feel like myself again! I continue to take it daily because not only does it reduce my irritability and depressed feelings, I feel like it gives me more energy - which I need!"

- Whitney from Louisville, KY 

"I have been using Denovo since May of 2019 because I suffer from depression. I was taking four prescriptions to battle my symptoms. Since I began taking Denovo, I have been able to cut down to one prescription. The combination of the prescription antidepressant and Denovo resulted in my moods leveling. I do not feel like I am always up or down anymore. I feel amazing! I have not been able to say that in a long time. My husband has also begun taking Denovo and says that he has more energy."

- Lori from Lilburn, GA

Note: The statements in all testimonials are the opinions of the contributor and have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.