Denovo Plus B12 15 mg L-Methylfolate Calcium

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Introducing DENOVO PLUS B12: Your Solution for Balancing Mood and Energy.

DENOVO PLUS B12 stands out as an exceptional dietary supplement meticulously designed to provide comprehensive support for managing low folate and B12 levels, which are often associated with symptoms of depression. This innovative formula offers a targeted approach to address these imbalances, promoting a more vibrant and balanced mental state.

At the heart of DENOVO PLUS B12 lies its unique active form of folate. Its efficacy and affordability set this supplement apart, offering competitive pricing compared to similar brands. By harnessing the power of this active folate, DENOVO PLUS B12 contributes to the production of crucial neurotransmitters such as serotonin, dopamine, and norepinephrine. These neurotransmitters are indispensable in mitigating feelings of sadness, anxiety, and gloom, ultimately fostering a sense of emotional well-being.

In addition to its folate benefits, DENOVO PLUS B12 contains a substantial daily dosage of at least 500mcg of Vitamin B12. This key vitamin plays a pivotal role in energizing your body and mind. Vitamin B12 further enhances the overall mood-enhancing effects of this supplement by stimulating serotonin production and diminishing stress levels.

It's important to note that individuals experiencing symptoms of depression often exhibit deficiencies in both folate and Vitamin B12. DENOVO PLUS B12 is formulated with this understanding in mind, addressing the fundamental need for adequate folate intake to support the synthesis of serotonin, dopamine, and norepinephrine. The recommended minimum daily dosage of 500mcg (equivalent to 1/2 mg) of active folate ensures that your body is supplied with the necessary nutrients to produce these essential neurotransmitters.

In conclusion, DENOVO PLUS B12 is not just a dietary supplement – it's a strategic solution for achieving mood balance and sustained energy. By effectively targeting low folate and Vitamin B12 levels, this formula empowers you to reclaim a more positive outlook on life. Say goodbye to the limitations of depression-related symptoms and welcome a brighter, more energized future with DENOVO PLUS B12.

Made in the USA

Supplement Facts

Active Ingredients: 15 mg L-methylfolate (L-5-MTHF from L-5-methyltetrahydrofolate calcium salt) & 2 mg (2,000 mcg) of vitamin B12 (as methylcobalamin).

Inactive Ingredients: microcrystalline cellulose, gelatin, vegetable magnesium stearate, silica, titanium dioxide, FD&C yellow #5k, FD&C yellow #6

Uses: Denovo is indicated for the distinct metabolic requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and or red blood cells and have a major depressive disorder (MDD) with particular emphasis as adjunctive support for individuals who are on an antidepressant medication.

L-methylfolate supplements are also used in people with a major depressive disorder who have folate deficiency or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency. (Source UofMH)

Folic acid, when administered in daily doses above 0.1mg, may obscure the detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations.) 5-MTHF may be less likely than folic acid to mask B12 deficiency. Folate therapy alone is inadequate for the treatment of B12 deficiency.

Caution is recommended in patients with a history of bipolar illness. Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder. 


Take one capsule daily or as recommended by your healthcare professional.

Each bottle contains 30 tablets.

What People Say

"After giving birth, I struggled with postpartum depression. I had been on prescription antidepressants and did not want to go on one again due to the associated side effects. Denovo was recommended to me as an alternative. It is truly a fantastic product! It worked just as well, if not better, than the antidepressants I have been on in the past. Denovo helped me feel like myself again! I continue to take it daily because not only does it reduce my irritability and depressed feelings, I feel like it gives me more energy - which I need!"

- Whitney from Louisville, KY 

"I have been using Denovo since May of 2019 because I suffer from depression. I was taking four prescriptions to battle my symptoms. Since I began taking Denovo, I have been able to cut down to one prescription. The combination of the prescription antidepressant and Denovo resulted in my moods leveling. I do not feel like I am always up or down anymore. I feel amazing! I have not been able to say that in a long time. My husband has also begun taking Denovo and says that he has more energy."

- Lori from Lilburn, GA

Note: The statements in all testimonials are the opinions of the contributor and have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.